Cimetidine (Tagamet) and mental problems

Tagamet, frequently prescribed for peptic ulcer disease, may be associated with manic behavior and previously has been reported to cause temporary mental confusion in some patients. Two patients given Tagamet for two to three months became agitated, hyperactive and euphoric (having an excessive sense of well-being). Symptoms resolved five days after discontinuing the use of the Tagamet. One of the patients was again given Tagamet with return of the mental symptoms. (Journal of Clinical Psychiatry 44:267-268, 1983) Copyright 1985 Phylis Austin

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